EC Number | Cloned (Comment) | Organism |
---|---|---|
3.4.22.49 | enhanced cyclin-dependent kinase 1 activity due to deregulation of CDC27-anaphase-promoting complex leads in turn to hyperphosphorylation of Separase, impeding chromatid separation. Regulation of mitotic progression by transforming growth factor-beta in bone marrow stromal cells is through targeting the APC-separase pathway | Mus musculus |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
3.4.22.49 | S1126A | specifically abolished separase hyperphosphorylation in Smad3-deficient cells | Mus musculus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.22.49 | Mus musculus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.4.22.49 | bone marrow stromal cell line | - |
Mus musculus | - |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.22.49 | separase | - |
Mus musculus |